Ozempic and Fertility: Insights from Dr. Jamie Stanhiser

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Ozempic & Fertility: Insights from a Reproductive Endocrinologist

Key Takeaways
  • Ozempic is not a fertility drug but may indirectly support fertility by promoting weight loss and improving insulin sensitivity, especially in individuals with PCOS or obesity.
  • You should stop taking Ozempic at least two months before trying to conceive due to potential risks to early fetal development.
  • Weight loss from Ozempic can restore ovulation, leading to a higher chance of unintended pregnancy—especially if birth control is less effective due to the medication.

Ozempic’s Role in Fertility

Ozempic (semaglutide) is a GLP-1 receptor agonist primarily prescribed for managing type 2 diabetes and aiding in weight loss. While not a fertility medication, its effects on weight and insulin sensitivity can indirectly impact reproductive health.

The Connection Between Weight, PCOS, and Fertility

Obesity and conditions like polycystic ovary syndrome (PCOS) can disrupt hormonal balance, leading to irregular ovulation and reduced fertility. Dr. Jamie Stanhiser, a reproductive endocrinologist at RPSD, emphasizes that even modest weight loss—about 5-10% of total body weight—can restore ovulatory cycles in many women, enhancing their chances of conception.

For individuals with PCOS, weight loss achieved through medications like Ozempic can improve insulin resistance and hormonal profiles, potentially leading to more regular menstrual cycles and improved fertility outcomes.

Ozempic Use During Pregnancy

While weight loss can positively influence fertility, it’s crucial to approach Ozempic use with caution when planning to conceive. Dr. Stanhiser advises discontinuing Ozempic at least two months before attempting pregnancy. This recommendation stems from the drug’s half-life and the time it takes to clear from the body, ensuring it doesn’t affect early fetal development.

Animal studies have indicated potential risks to fetal development when exposed to semaglutide, including reduced fetal weight and skeletal abnormalities. Although human data is limited, the precautionary principle suggests avoiding Ozempic during pregnancy until more comprehensive studies are available.

Unintended Pregnancies and Contraceptive Considerations

An emerging concern is the occurrence of unintended pregnancies among Ozempic users. Weight loss can restore ovulation in individuals who previously experienced an ovulation, increasing the likelihood of conception. Additionally, some reports suggest that GLP-1 receptor agonists may interfere with the absorption of oral contraceptives due to delayed gastric emptying, potentially reducing their effectiveness.

Dr. Stanhiser recommends that individuals using Ozempic and not planning to conceive should consider using additional or alternative contraceptive methods to prevent unintended pregnancies.

Personalized Guidance at RPSD

At Reproductive Partners Fertility Center – San Diego, we understand the complexities surrounding weight management, medication use, and fertility. Our team, including experts like Dr. Stanhiser, is dedicated to providing personalized care plans that consider each patient’s unique circumstances.

If you’re considering Ozempic as part of your health regimen and are planning to conceive, or if you have concerns about its implications on fertility, we encourage you to schedule a consultation with our specialists. Together, we can navigate the best path forward for your reproductive goals.

Schedule a consultation with one of RPSD’s expert, double board-certified fertility specialists at our San Diego fertility center.