IUI vs IVF: How Many Times Should You Try IUI Before Moving to IVF?

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happy couple hugging after successful IVF fertility treatment

Key Takeaways
  • Most fertility specialists recommend 3–6 IUI cycles before considering IVF, depending on age and fertility diagnosis.
  • IVF offers higher success rates per cycle, especially for patients over 35 or with certain conditions.
  • The decision should be based on medical, emotional, and financial factors.
  • Reproductive Partners Fertility Center – San Diego provides individualized guidance on when it’s time to pivot your fertility treatment.

How Many IUI Cycles Should You Try Before IVF?

If you’re undergoing fertility treatment, chances are you’ve asked yourself, “How many IUIs should I try before moving to IVF?” It’s one of the most common questions we hear at Reproductive Partners Fertility Center–San Diego (RPSD), and the answer depends on several key factors.

What Is IUI?

Intrauterine insemination (IUI) is often a first-line fertility treatment, especially for unexplained infertility, mild male factor, or single parents and LGBTQ+ couples using donor sperm. It’s a less invasive and more affordable option than in vitro fertilization (IVF).

But while IUI can work well for many patients, it doesn’t have the same success rates as IVF—especially as age increases or if underlying fertility issues exist.

What Does the Research Say?
  • Under 35 years old with no major fertility diagnosis: Most patients try 3–4 cycles of IUI before moving on to IVF.
  • 35–37 years old: Consider switching after 2–3 unsuccessful IUIs, especially if time is a factor.
  • 38 and older: Many specialists recommend skipping IUI altogether or moving to IVF after 1–2 IUIs, due to rapidly declining egg quality.
  • Diagnosis-based exceptions: If you have blocked fallopian tubes, severe male factor infertility, or diminished ovarian reserve, IVF may be the first and only recommended option.

When to Consider Moving to IVF

You might want to consider transitioning from IUI to IVF if:
  • You’ve completed 3–6 IUI cycles without success
  • You have limited ovarian reserve or are age 35+
  • You’ve experienced multiple early pregnancy losses
  • You’re dealing with endometriosis, blocked tubes, or male factor infertility
  • You want to increase your chances of success more quickly
  • You’re ready for more control—IVF allows for genetic testing (PGT), embryo freezing, and more precision

The RPSD Approach: Personalized Fertility Plans

At RPSD, we don’t believe in one-size-fits-all treatment. Our double board-certified physicians assess your age, diagnosis, fertility goals, and emotional readiness before making any recommendations. We’ll guide you through each cycle with honest communication and evidence-based insights.

What’s Next?

If you’ve been trying IUI without success, it might be time to explore your next move. IVF may feel like a big leap—but with the right support and a tailored treatment plan, it can bring you one step closer to the family you’ve been dreaming of.

Schedule a consultation with our San Diego fertility specialists to discuss your options.