Letrozole is a medication used to treat infertility in women. It is a type of aromatase inhibitor that works by reducing the amount of estrogen in the body. This can help to stimulate ovulation and increase the chances of pregnancy. Letrozole is usually taken orally, once a day, for five days, starting on the third day of the menstrual cycle. This medication is generally well tolerated and has been shown to be effective in inducing ovulation and pregnancy in women who are having trouble conceiving. Recent studies have suggested that letrozole may be more effective than clomiphene citrate in women with polycystic ovarian syndrome (PCOS).
Letrozole has a half-life of only two days, which means that when taken during the early part of your menstrual cycle, it should be eliminated from your body prior to ovulation.
Despite many studies suggesting its safety and efficacy, the FDA has not yet approved letrozole for fertility treatment. Therefore, although commonly used for fertility treatment, letrozole is considered an “off-label” medication when used as a fertility treatment.
Side effects: Most patients do not have side effects with letrozole, although possible side effects include multiple pregnancy, mild nausea, fatigue, or joint and muscle pain.